Clinical characteristics and prognosis of patients with adult T-cell leukemia lymphoma

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Published

2022-12-07

How to Cite

Valdivieso Lama, N., Barrionuevo Cornejo, C., Vidal Ayllon, J., Casanova Marquez, L., Flores Flores, C., López Chavez, L., Alcarraz Molina, C., Ruiz Mendoza, R., & Quintana Truyenque, S. (2022). Clinical characteristics and prognosis of patients with adult T-cell leukemia lymphoma. Oncology Journal (Ecuador), 32(3), 320–333. https://doi.org/10.33821/657

Issue

Vol. 32 No. 3 (2022): December - March

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Original Articles

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Copyright (c) 2022 Natalia Valdivieso Lama, Carlos Barrionuevo Cornejo, Judith Vidal Ayllon, Luis Casanova Marquez, Claudio Flores Flores, Lourdes López Chavez, Cindy Alcarraz Molina, Rossana Ruiz Mendoza, Shirley Quintana Truyenque

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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Authors

  • Natalia Valdivieso Lama National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru. https://orcid.org/0000-0002-4300-5958
  • Carlos Barrionuevo Cornejo National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru.
  • Judith Vidal Ayllon National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru.
  • Luis Casanova Marquez Aliada, Oncological center, Lima, Perú
  • Claudio Flores Flores Research Department, Oncosalud, Lima, Peru https://orcid.org/0000-0002-3659-4993
  • Lourdes López Chavez Oncology Department, National Institute of Neoplastic Diseases, Lima, Peru
  • Cindy Alcarraz Molina National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru.
  • Rossana Ruiz Mendoza National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru. https://orcid.org/0000-0001-5199-6686
  • Shirley Quintana Truyenque National Institute of Neoplastic Diseases, INEN, Privaty University San Juan Bautista, Lima, Peru.

DOI:

https://doi.org/10.33821/657

Keywords:

Leukemia-Lymphoma, Adult T-Cell, Human T-lymphotropic virus 1, Study Characteristics, Immuno-phenotyping, Tertiary Treatment

Abstract

Introduction: The objective of this study was to determine the clinical characteristics and prognosis of patients with adult T-cell leukemia/lymphoma (ATL) at the National Institute of Neoplastic Diseases (INEN) of Peru.

Methodology: A cross-sectional study was carried out, which included 188 clinical histories and a pathological study of patients diagnosed with HTLV-1 infection diagnosed at the INEN for ten years, of whom 150 had ATL.

Results: Sixty-two percent of the patients had the ATL lymphoma subtype, 37% had the acute subtype, and 1% had the chronic subtype. The median age was 53 (20-89); 51% were women. Within the clinical characteristics: ECOG >or =2 (56%); clinical stage III-IV (80%), symptoms B (58%); increased lactic dehydrogenase, LDH, (74%); leukocytosis (50%); hypercalcemia (46%) and anemia (36%). A total of 122 patients (81.3%) received treatment, 79% with chemotherapy (CT) and 4.6% with complementary radiotherapy (RT); CHOP was the most frequent QT regimen (89%). Of the patients with QT, 18% had CR, 32% PR, 7% EE, and 13% PE.

Conclusion: In this report, in patients with ATL, the lymphoma form was the most frequent subtype, and there was a high prevalence of atypical immunophenotype and poor response to CHOP.

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