Mature Cystic Teratoma of the mediastinum in an adolescent patient: case report and literature review

Published

2025-01-15

How to Cite

Gagliardo Cadena, E., Campoverde Vilela, N., Bombón Caizaluisa, M. F., & Zambrano García, L. (2025). Mature Cystic Teratoma of the mediastinum in an adolescent patient: case report and literature review. Oncology Journal (Ecuador), 34(3), 92–101. https://doi.org/10.33821/762

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Section

Case Reports

Authors

DOI:

https://doi.org/10.33821/762

Keywords:

mature cystic teratoma, germinal tumor, mediastinal lesion, adolescent

Abstract

Introduction: Mature cystic mediastinal teratoma is a primary germ cell neoplasm with benign features, composed of fully differentiated tissues derived from more than one of the three embryonic germ cell layers, occurring mainly in adolescents and young adults. They occur most frequently in the anterior compartment, secondarily at the level of the thymus and rarely in the posterior compartment. Clinical case: We present the case of a 13-year-old adolescent patient with an apparent mediastinal tumor, which caused moderate chest pain, dyspnea on moderate exertion accompanied by asthenia and progressive weight loss. Treatment: Total resection of the anterior mediastinal tumor is performed, which confirms the histopathological diagnosis of solid cystic mature tridermal cystic teratoma of the mediastinum, with negative lymph nodes for malignancy. Conclusion: Mature cystic teratoma is the most frequent pathology of mediastinal tumors, of benign characteristics, with non-specific symptomatology. Surgical resolution remains the gold standard in terms of treatment, with low recurrence rates after complete surgical resection and with a good short, medium and long term prognosis.

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Author Biographies

Enrique Gagliardo Cadena, Hospital SOLCA

Servicio de Cirugía Torácica, Hospital SOLCA. Guayaquil, Ecuador

Nathaly Campoverde Vilela, Hospital SOLCA

Servicio de Cirugía Torácica, Hospital SOLCA. Guayaquil.

Marco Fabricio Bombón Caizaluisa, Universidad de Especialidades Espíritu Santo

Servicio de Cirugía Torácica, Hospital SOLCA. Guayaquil. Postgrado de Cirugía, SOLCA, Guayaquil. Universidad de Especialidades Espíritu Santo. Samborondón.

Luis Zambrano García, Hospital SOLCA

Servicio de Cirugía Torácica, Hospital SOLCA. Guayaquil.

References

Masdeu M, Nuñez T, Torres R, Codinado C, Portas T. Teratoma mediastinal con áreas de malignidad, reporte de un caso y discusión. Rev Am Med Respir. 2022; 22(1):57-61.

González P, Colmenares J, Sentelices M, Pérez L. Resección completa en dos tiempos de teratoma quístico gigante del mediastino que debuta con compromiso vital. Rev Cir 2023; 75(3):190-193.

Barabrah AM, Zaben B, Tuqan AR, Sala O, Hakam Shehadeh M, Eideh H, et al. Mature Cystic Teratoma of Anterior Mediastinum in a Child: A Case Report and Literature Review. J. Investig. Med. High Impact Case Rep. 2024; 12. DOI:10.1177/23247096241274510

Fuentes E, Pérez K. Teratomas gigantes en tórax. Neumol Cir Torax. 2018; 77(3):209-212.

Aguiñaga O, Maldonado F. Teratoma maduro mediastinal. Tratamiento con radioterapia externa hipofraccionada: reporte de caso. Gact Mex Oncol. 2023; 22:116-120. DOI: 10.24875/j.gamo.23000142

Ram D, Sharma DK, Darlong LM, Rajappa SK, Bhakuni YS. Mediastinasl teratoma with pulmonary parenchyma fistula: a rare diagnostic endeavour. J Clin Diagn Res. 2017; 11(8): XD03-XD04. DOI: 10.7860/JCDR/2017/28238.10438

Ghareeb A, Al Sharif F, Alyousbashi A, Dawarah M, Ghareeb A, Dalati H. Mediastinal mature cystic teratoma in a child: A case report study. Int J Surg Case Rep. 2023; 103:107904. DOI: 10.1016/j.ijscr.2023.107904

Alonso G, Suárez Y. Teratoma Mediastinal: informe de caso. Acta méd centro. 2018; 12(1):70-74.

Kebalo SP, Lamboni D, Guedenon KM, Amegbor K, Gnassingbe K. Mature teratoma of the mediastinum in children: a case revealed by persistent chest pain. J Pediatr Surg Case Rep. 2022; 78:102209. https://doi.org/10.1016/j.epsc.2022.102209

Arce-Aranda C, Ayala-Guzmán JD, Cuevas-Zapata JF, Duarte-González AL, Garay-Gómez CD, GutiérrezCodas GM, et al. Frequency, classification and pathology of mediastine tumors. Rev Cir Parag [En línea]. 2018; 42(2):17-22. DOI: 10.18004/sopaci.2018.agosto.17-22

López M, Silva O, Carvajal A. Teratoma gigante de mediastino anterior con taponamiento cardiaco. Rev Med Hered. 2012; 23(3):199-203.

Raoufi M, Herrak L, Benali A, Achaachi L, El Ftouh M, Bellarbi S, et al. Mediastinal mature teratoma revealed by empyema. Case rep pulmonol. 2016; 1-4. https://doi.org/10.1155/2016/7869476

Fuentes E. Teratomas del mediastino. Rev Cubana Cir. 2020; 59(3): 1-15.

Kuroda H, Hashidume T, Shimanouchi M, Sakao Y. Resection of a ruptured mature cystic teratoma diagnosed two years after the onset of perforation. World J Surg Oncol. 2014; 12:321-323. DOI: 10.1186/1477- 7819-12-321

García H, Borrazas M, Fernandez M. Teratoma mediastinal anterior. Rev. cuba. med. mil. 2016; 45(2): 229-234.

Pamo-Reyna OG, Bendezu-Huasasquiche LE, Chian-García C. Teratoma quístico maduro mediastínico que se presenta como hemoptisis. Rev Soc Peru Med Interna. 2018; 31(1):27-30.

Sato D, Izu A, Sakakibara M, Hayashi S, Kawachi R, Shimamura M, et al. A neuroendocrine tumor within an anterior mediastinal mature teratoma: a case report. J Cardiothorac Surg. 2022; 17:333. DOI: 10.1186/s13019-022-02091-3

Peterson CM, Buckley C, Holley S, Menias CO. Teratomas: a multimodality review. Curr Probl Diagn Radiol. 2012; 41(1):210-219.

AlHarbi KM, Sairafi MH, Almuzaini SA. Mature cystic teratoma of mediastinum compressing the right atrium in a child: a rare case report. J Taibah Univ Med Sci. 2017; 12(6):555-560. https://doi.org/10.1016/j.jtumed.2017.06.007

Yasa KP, Permana AACT, Dewi SM. Mediastinal benign mature teratoma in young girl, catastrophic delayed and complications of surgery: a case report. Open Access Maced J Med Sci. 2020; 8:201-204. https://doi.org/10.3889/oamjms.2020.3363

Varma AV, Malpani G, Agrawal P, Malukani K, Dosi S. Clinicopathological spectrum of teratomas: An 8-year retrospective study from a tertiary care institute. Indian J Cancer. 2017 Jul-Sep;54(3):576-579. DOI: 10.4103/ijc.IJC_294_17

Nusjirwan R, Hermawan K, Dewi M, Nugraha HG, DewaYani BM, Nataprawira HM.S. Mediastinal teratoma in a children: a case series of misdiagnoses in a high-endemic tuberculosis setting. Int J Surg. 2023; 116:109307. https://doi.org/10.1016/j.ijscr.2024.109307

Liew WX, Lam HY, Narasinmamman S, Navarasi S, Mohd Hamzah K. Mediastinal mature teratoma in a child: a case report. Med J Malaysia. 2016; 116:109307.

Anand S, Longia S, Agarwal N, Maheshwari M, Apte A, Pathak K. Mature mediastinal teratoma. A rare cause of recurrent respiratory distress. Peoples J Sci Res. 2010; 3:33-35.

Rodríguez López-Calleja CA, Mayea Sánchez F, González Zayas A, López Marín L. Resección por toracoscopia del teratoma mediastinal. Rev Cubana Cir. 2015; 54(1):43-49.

AlHarbi KM, Sairafi MH, Almuzaini SA. Mature cystic teratoma of mediastinum compressing the right atrium in a child: a rare case report. J Taibah Univ Med Sci. 2017; 12(6):555-560. https://doi.org/10.1016/j.jtumed.2017.06.007

Agarwal S, Mullick S, Gupta K, Dewan RK. Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature. Turk Thorac J. 2015; 16(2):101-4. DOI: 10.5152/ttd.2014.4280

Nozaki I, Tone Y, Yamanaka J, Uryu H, Shimizu-Motohashi Y, Sato N, et al. A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma. Case Rep Pediatr. 2018; 1:1-5. DOI: 10.1155/2018/1306824

Al Smady M, Zahari NNB, Mohd Sahid NSB, et al. Anterior mediastinal teratoma with pericardial effusion. Rare presentation. J Surg Case Rep. 2019; 5(1):1-3. https://doi.org/10.1093/jscr/rjz136

Ruiz M, Zarate L, Alfonso J, Polo F. Teratoma del mediastino anterior. Repert. med. cir. 2012; 21(2):132-135. https://doi.org/10.31260/RepertMedCir.v21.n2.2012.808