Solitary Fibrous Tumor of the Pleura: Clinical Case Report
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Iliana Encalada Valdivieso, Tannia Rivera Rivera, Fernando Salazar Reinoso, Edwin Ross Rodriguez
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
DOI:
https://doi.org/10.33821/793Keywords:
solitary fibrous tumor of the pleura, pleural neoplasm, thoracic surgeryAbstract
Introduction: Solitary fibrous tumor (SFT) of pleura is a rare neoplasm that originates from mesenchymal cells underlying the pleura. Its clinical course is usually indolent until it reaches large dimensions, producing symptoms due to compression. This clinical case provides valuable evidence on the effective diagnosis and management of this rare tumor. It also highlights the usefulness of molecular tools and oncological surveillance. Clinical case: We present a clinical case of a 53-year-old female patient diagnosed with SFT of pleura, treated by surgical resection and followed up for 6 years. Results: The patient presented with cough and dyspnea. Chest computed tomography revealed a 23 cm left pleural mass. Histopathological study confirmed SFT with intermediate risk of recurrence. No recurrence was evident in subsequent follow-up. Conclusions: SFT of pleura requires early diagnosis, complete surgical resection, and follow-up. Stratification of recurrence risk is essential for clinical management.
Downloads
References
Martin-Broto J, Mondaza-Hernandez JL, Moura DS, Hindi N. A comprehensive review on solitary fibrous tumor: New insights for new horizons. Vol. 13, Cancers. MDPI; 2021. https://doi.org/10.3390/cancers13122913
Kallen ME, Hornick JL. The 2020 WHO Classification: What’s New in Soft Tissue Tumor Pathology? Am J Surg Pathol. 2021;45(1):e1-e23. https://doi.org/10.1097/PAS.0000000000001552
Organización Mundial de la Salud, Grupo Editorial de la Clasificación de Tumores. Clasificación de los tumores de la OMS. Tumores de tejidos blandos y de hueso. 5ª ed. Vol. 3. Lyon: Agencia Internacional para la Investigación sobre el Cáncer (IARC); 2020. Disponible en: https://publications.iarc.who.int/608
Thway K, Ng W, Noujaim J, Jones RL, Fisher C. The Current Status of Solitary Fibrous Tumor. Vol. 24, International Journal of Surgical Pathology. SAGE Publications Inc.; 2016. p. 281-92. https://doi. org/10.1177/1066896915627485
Fatimi S hasnain, Inam H, Chagan FK, Choudry UK. Solitary fibrous pleural tumor. A rare and challenging case. Int J Surg Case Rep. 2020;66:346-9. https://doi.org/10.1016/j.ijscr.2019.12.020
Almeida Costa N, Fonseca D, Santos J. Extra-pleural solitary fibrous tumors: A review. Egypt J Radiol Nucl Med. 2019;50:42. https://doi.org/10.1186/s43055-019-0040-9
Martin-Broto J, Cruz J, Penel N, Le Cesne A, Hindi N, Luna P, et al. Pazopanib for treatment of typical solitary fibrous tumours: A multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020;21(3):456-66. https://doi. org/10.1016/S1470-2045(19)30826-5
Demicco EG, Wagner MJ, Maki RG, Gupta V, Iofin I, Lazar AJ, et al. Risk assessment in solitary fibrous tumors: Validation and refinement of a risk stratification model. Modern Pathology. 2017;30(10):1433-42. https://doi. org/10.1038/modpathol.2017.54
Xiao Y, Chen J, Yang W, Yan H, Chen R, Li Y. Solitary fibrous tumors: radiologic features with clinical and histopathologic correlation. Front Oncol. 2025;15:1510059. https://doi.org/10.3389/fonc.2025.1510059
Georgiesh T, Boye K, Bjerkehagen B. A novel risk score to predict early and late recurrence in solitary fibrous tumour. Histopathology. 2020;77(1):123-32. https://doi.org/10.1111/his.14078
de Bernardi A, Dufresne A, Mishellany F, Blay JY, Ray-Coquard I, Brahmi M. Novel therapeutic options for solitary fibrous tumor: Antiangiogenic therapy and beyond. Vol. 14, Cancers. MDPI; 2022. https://doi. org/10.3390/cancers14041064
